安倍经济学/Paritaprevir/5 mg/15-4006-免疫在线蚂蚁淘旗下平台

商品详细安倍经济学/Paritaprevir/5 mg/15-4006

安倍经济学/Paritaprevir/5 mg/15-4006

商品编号： 15-4006

品牌： Abeomics

市场价： ¥5000.00

美元价： 2500.00

产地：美国(厂家直采)

公司：

产品分类：酶抑制剂

公司分类： Enzyme_Inhibitors

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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Amount :	10 mg
Purification :	≥98%
Content :	Paritaprevir is supplied as a solid.
Storage condition :	Store at -20°C, product is stable for at least two years.


Alternative Name :	ABT-450

Molecular Formula:C₄₀H₄₃N₇O₇S

Molecular Weight:765.9

Paritaprevir is an orally bioavailable, direct-acting inhibitor of the hepatitis C virus (HCV) non-structural 3/4A (NS3/4A) serine protease.It inhibits HCV replication in stable Huh7-derived replicon cell lines infected with subgenomic genotypes 1a, 1b, 2a, 3a, 4a, and 6a (EC50s = 1, 0.21, 5.3, 19, 0.09, and 0.69 nM, respectively). It also inhibits replicons from clinical isolates of genotypes 1a (EC50s = 0.43-1.87 nM) and 1b (EC50s = 0.033-0.087 nM). Formulations containing paritaprevir in combination with ombitasvir, ritonavir, and dasabuvir with and without ribavirin have been used in the treatment of chronic HCV genotype 1 infection.

A stock solution may be made by dissolving the paritaprevir in the solvent of choice, which should be purged with an inert gas. Paritaprevir is soluble in organic solvents such as DMSO and dimethyl formamide. The solubility of paritaprevir in these solvents is approximately 30 mg/ml.

Paritaprevir is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, paritaprevir should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Paritaprevir has a solubility of approximately 0.17 mg/ml in a 1:5 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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