Abeomics/Simeprevir(钠盐)/1毫克/15-4005
市场价:
¥1800.00
美元价:
900.00
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Amount : | 5 mg |
Purification : | ≥98% |
Content : | Simeprevir (sodium salt) is supplied as a crystalline solid. |
Storage condition : | Store at -20°C, product is stable for at least two years. |
Molecular Formula:C38H47N5O7S2 • XNa
Molecular Weight:749.9
Simeprevir is an orally bioavailable and potent inhibitor of the hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A) protease (Ki = 0.36 nM), a serine protease essential for HCV replication.It inhibits HCV viral replication with an EC50 value of 7.8 nM in Huh7 replicon cells using a luciferase-based assay. Simeprevir is effective against the HCV genotypes 1a and 1b in biochemical assays.In Huh7 replicon cells,it is synergistically effective when used in combination with IFN-α or NM-107 and has an additive effect when used with ribavirin (Item No. 16757). Formulations containing simeprevir have been used, alone or in combination with pegylated IFN-α and ribavirin, for the treatment of HCV.
A stock solution may be made by dissolving the simeprevir (sodium salt) in the solvent of choice. Simeprevir (sodium salt) is soluble in organic solvents such as DMSO and dimethyl formamide, which should be purged with an inert gas. The solubility of simeprevir (sodium salt) in these solvents is approximately 30 mg/ml. Simeprevir (sodium salt) is also slightly soluble in ethanol.
Simeprevir (sodium salt) is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, simeprevir (sodium salt) should first be dissolved in DMSO and then diluted with the aqueous buffer of choice. Simeprevir (sodium salt) has a solubility of approximately 0.33 mg/ml in a 1:2 solution of DMSO:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
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品牌介绍
Abeomics由一组经验丰富的科学家组成,他们还建立了成功的全球业务,其中包括世界一流的生命科学试剂和合同实验室服务提供商IMGENEX Inc.,以及用于系统生物学和临床医学的复杂的交互式网络数据库Protein Lounge。生物信息学。
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