安倍经济学/达诺普利/1毫克/15-4004-免疫在线蚂蚁淘旗下平台

商品详细安倍经济学/达诺普利/1毫克/15-4004

安倍经济学/达诺普利/1毫克/15-4004

商品编号： 15-4004

品牌： Abeomics

市场价： ¥2400.00

美元价： 1200.00

产地：美国(厂家直采)

公司：

产品分类：酶抑制剂

公司分类： Enzyme_Inhibitors

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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Amount :	5 mg
Purification :	≥95%
Content :	Danoprevir is supplied as a crystalline solid.
Storage condition :	Store at -20°C, product is stable for at least two years.


Alternative Name :	ITMN-191, R-7227

Molecular Formula:C₃₅H₄₆FN₅O₉S

Molecular Weight:731.8

Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC50 = 1 nM), a serine protease essential for HCV replication.It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s = 0.2-0.4 nM) as well as 2b and 3a (IC50s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC50 = 1.8 nM).

A stock solution may be made by dissolving the danoprevir in the solvent of choice. Danoprevir is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of danoprevir in these solvents is approximately 15, 25, and 30 mg/ml, respectively.

Danoprevir is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, danoprevir should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Danoprevir has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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