安倍经济学/格拉佐普雷韦/5毫克/15-4003-免疫在线蚂蚁淘旗下平台

商品详细安倍经济学/格拉佐普雷韦/5毫克/15-4003

安倍经济学/格拉佐普雷韦/5毫克/15-4003

商品编号： 15-4003

品牌： Abeomics

市场价： ¥2400.00

美元价： 1200.00

产地：美国(厂家直采)

公司：

产品分类：酶抑制剂

公司分类： Enzyme_Inhibitors

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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Amount :	10 mg
Purification :	≥98%
Content :	Grazoprevir is supplied as a crystalline solid.
Storage condition :	Store at -20°C.


Alternative Name :	MK-5172

Molecular Formula:C₃₈H₅₀N₆O₉S

Molecular Weight:766.9

Grazoprevir is a pan-genotypic protease inhibitor that binds to hepatitis C virus (HCV) non-structural protein 3/4A (NS3/4A), a serine protease essential for viral replication.Grazoprevir has potent in vitro activity against major HCV genotypes (Kis = 0.1, 0.1, 0.08, 0.15, and 0.9 nM for genotypes 1a, 1b, 2a, 2b, and 3a, respectively) and common resistance genotypes (Kis = 0.07, 0.14, and 0.30 nM for genotypes 1b R155K, D165V, and D168Y, respectively). Grazoprevir inhibits the NS3/4A protease in an in vitro replicon system with EC50 values of 2 and 8 nM for genotypes 1a and 2a, respectively. Formulations containing grazoprevir are used in combination therapies to treat HCV.

A stock solution may be made by dissolving the grazoprevir in the solvent of choice. Grazoprevir is soluble in organic solvents such as ethanol, DMSO, and dimethyl formamide (DMF), which should be purged with an inert gas. The solubility of grazoprevir in these solvents is approximately 15, 25, and 30 mg/ml, respectively.

Grazoprevir is sparingly soluble in aqueous buffers. For maximum solubility in aqueous buffers, grazoprevir should first be dissolved in DMF and then diluted with the aqueous buffer of choice. Grazoprevir has a solubility of approximately 0.2 mg/ml in a 1:4 solution of DMF:PBS (pH 7.2) using this method. We do not recommend storing the aqueous solution for more than one day.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

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