Abeomics/抗MUC1/EMA/CD227（上皮标记物）的重组小鼠单克隆抗体（克隆：rMUC1/960）/20µg/12-1008-免疫在线蚂蚁淘旗下平台

商品详细Abeomics/抗MUC1/EMA/CD227（上皮标记物）的重组小鼠单克隆抗体（克隆：rMUC1/960）/20µg/12-1008

Abeomics/抗MUC1/EMA/CD227（上皮标记物）的重组小鼠单克隆抗体（克隆：rMUC1/960）/20µg/12-1008

商品编号： 12-1008

品牌： Abeomics

市场价： ¥3980.00

美元价： 1990.00

产地：美国(厂家直采)

公司：

产品分类：电源

公司分类： power_pack

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Format :	Purified
Amount :	100 µg
Isotype :	Mouse IgG2b, kappa
Purification :	Purified Ab with BSA and Azide at 200ug/ml
Content :	200ug/ml of Ab purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM PBS with 0.05% BSA & 0.05% azide. Also available WITHOUT BSA & azide at 1.0mg/ml.
Storage condition :	Store the antibody at 4°C; stable for 6 months. For long-term storage; store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	MUC1
Gene ID :	4582
Uniprot ID :	P15941
Alternative Name :	Breast carcinoma-associated antigen DF3,CA15-3,Carcinoma-associated mucin Episialin,Epithelial Membrane Antigen,H23AG,KL-6,MAM6,MUC-1,MUC-1/SEC,MUC-1/X,MUC1-alpha,MUC1-beta,MUC1-CT,MUC1-NT,MUC1/ZD,Mucin 1 cell surface associated,Mucin-1 subunit beta,Peanut-reactive urinary mucin,PEM,PEMT,Polymorphic epithelial mucin,PUM,Tumor-associated epithelial membrane antigen
Immunogen Information :	Human milk-fat globule membranes (HMFGM)

This MAb reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The dominant epitope of this MAb involves both amino acids as well as sugar moieties. Neuraminidase treatment destroys the antigen. It is a very good tracer agent in CA15.3 assays. The extracellular domain of MUC1 largely consists of a highly conserved, O-glycosylated 20 amino acids tandem repeat which can occur 30-100 times per molecule depending on the length of the allele involved. In the vast majority of human carcinomas this protein is up-regulated and poorly glycosylated and appears on the cell surface in a non-polarized fashion.

MW : 265-400kDa; Positive Control : MCF-7 or MDA-231 cells. Breast, colon, ovarian, endometrial carcinoma.;Flow Cytometry (0.5-1ug/million cells); Immunofluorescence (1-2ug/ml); Immunohistology (Formalin-fixed) (0.5-1ug/ml for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cell membrane, Cytoplasm, Nucleus
Post transnational modification:	The N-terminal sequence has been shown to begin at position 24 or 28.
Tissue Specificity:	Expressed on the apical surface of epithelial cells, especially of airway passages, breast and uterus. Also expressed in activated and unactivated T-cells. Overexpressed in epithelial tumors, such as breast or ovarian cancer and also in non-epithelial tumor cells. Isoform Y is expressed in tumor cells only.
BioGrid:	110669.44 interactions.

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