抗Dapper同源物1/25µg/11-10012的Abeomics/多克隆抗体
市场价:
¥1600.00
美元价:
800.00
产品分类:
DNA修饰酶
公司分类:
DNA_modification_enzyme
联系Q Q:
3392242852
电话号码:
4000-520-616
电子邮箱:
info@ebiomall.com
商品介绍
Format : | Purified |
Amount : | 100 µg |
Isotype : | Rabbit IgG |
Purification : | Protein A Chromatography |
Content : | 25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic. |
Storage condition : | Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles. |
Gene : | DACT1 |
Gene ID : | 51339 |
Uniprot ID : | Q9NYF0 |
Alternative Name : | DACT1, DPR1, HNG3 |
Immunogen Information : | A partial length recombinant Dapper homolog 1 protein (amino acids 645-820) was used as the immunogen for this antibody. |
Dapper homolog 1 (DACT1) is a cytoplasmic protein and a member of DACT family. It is an important regulator in the planar cell polarity (PCP) pathway. DACT1 interacts and posttranslationally regulates central PCP components Dvl2 and Vangl2 and modulates PCP downstream of the Rac1/JNK cascade. The gene for DACT1 is located at chromosome 14q22.3, which encodes a 836 amino acid protein with a putative leucine zipper (LZ) domain in the amino-terminal end and a consensus PDZ binding (PDZ-B) motif in the carboxy-terminal end that allows the DACT1 protein to interact with the Dishevelled (Dvl) PDZ domain. DACT1 is an important positive regulator in colon cancer through regulating the stability and sublocation of Beta-catenin. The overexpression of DACT1 leads to the increased accumulation of nonphosphorylated Beta-catenin in the cytoplasm and particularly in the nuclei.It interacts with GSK-3beta and beta-catenin and stabilizes it via DACT1-induced effects on GSK-3beta which directly interacts with beta-catenin proteins. This interaction identifies DACT1 as an important positive regulator in colon cancer and suggests a potential strategy for the therapeutic control of the beta-catenin-dependent pathway.
Western blot analysis: 2-4 µg/ml
For Research Use Only. Not for use in diagnostic/therapeutics procedures.
Subcellular location: | Cytoplasm, Nucleus, Cell junction |
BioGrid: | 119486.19 interactions. |
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品牌介绍
Abeomics由一组经验丰富的科学家组成,他们还建立了成功的全球业务,其中包括世界一流的生命科学试剂和合同实验室服务提供商IMGENEX Inc.,以及用于系统生物学和临床医学的复杂的交互式网络数据库Protein Lounge。生物信息学。
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