ABOMICS/抗OPG单克隆抗体（克隆：ABM10D2）/25µg/10-6001-免疫在线蚂蚁淘旗下平台

商品详细ABOMICS/抗OPG单克隆抗体（克隆：ABM10D2）/25µg/10-6001

ABOMICS/抗OPG单克隆抗体（克隆：ABM10D2）/25µg/10-6001

商品编号： 10-6001

品牌： Abeomics

市场价： ¥1800.00

美元价： 900.00

产地：美国(厂家直采)

公司：

产品分类：抗过氧化物酶

公司分类： Anti_Peroxidase

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Format :	Purified
Amount :	100 µg
Isotype :	Mouse IgG1, Kappa
Purification :	Protein G Chromatography
Content :	25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition :	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	TNFRSF11B
Gene ID :	4982
Uniprot ID :	O00300
Alternative Name :	Tumor necrosis factor receptor superfamily member 11B, Osteoclastogenesis inhibitory factor, Osteoprotegerin
Immunogen Information :	A partial length recombinant protein (a.a 15-206)of OPG was used as the immunogen for this antibody.

OPG (Osteoprotegerin) belongs to the TNF receptor super-family and is implicated in bone remodeling and in the atherosclerotic process. This molecule acts as a decoy receptor for the RANKL (Receptor Activator of Nuclear Factor-KappaB Ligand), inhibiting binding of RANKL to its receptor, RANK. OPG acts as a soluble neutralizing receptor of TRAIL (TNF-Related Apoptosis-Inducing Ligand), an anti-inflammatory molecule with anti-atherosclerotic properties. Mostly implicated in bone remodeling, the RANK/RANKL/OPG axis is involved in immune and vascular system. OPG has been associated with increased risk of atherosclerotic disease in the general population. OPG has also been associated with increased pulse wave velocity, progression of arterial calcification and with mortality in both end-stage renal failure patients as well as the general population.

WB: 4-6 µg/ml, FACS: 0.5-1 µg/10^6

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Secreted
Post transnational modification:	The N-terminus is blocked.
Tissue Specificity:	Highly expressed in adult lung, heart, kidney, liver, spleen, thymus, prostate, ovary, small intestine, thyroid, lymph node, trachea, adrenal gland, testis, and bone marrow. Detected at very low levels in brain, placenta and skeletal muscle. Highly expressed in fetal kidney, liver and lung.
BioGrid:	111028.2 interactions.

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