Abeomics/小鼠抗GCG单克隆抗体（克隆：BS25）/0.1ml/10-12539-免疫在线蚂蚁淘旗下平台

商品详细Abeomics/小鼠抗GCG单克隆抗体（克隆：BS25）/0.1ml/10-12539

Abeomics/小鼠抗GCG单克隆抗体（克隆：BS25）/0.1ml/10-12539

商品编号： 10-12539

品牌： Abeomics

市场价： ¥9120.00

美元价： 4560.00

产地：美国(厂家直采)

公司：

产品分类：芯片

公司分类： Biochip

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Amount :	0.5 ml
Isotype :	Mouse IgG1
Content :	TRIS with 0.03% sodium azide, pH7.2
Storage condition :	Store at 4°C


Gene :	GCG
Gene ID :	2641
Uniprot ID :	P01275
Alternative Name :	Glucagon-like peptide 1, Glucagon-like peptide 2

The protein encoded by this gene is actually a preproprotein that is cleaved into four distinct mature peptides. One of these, glucagon, is a pancreatic hormone that counteracts the glucose-lowering action of insulin by stimulating glycogenolysis and gluconeogenesis. Glucagon is a ligand for a specific G-protein linked receptor whose signalling pathway controls cell proliferation. Two of the other peptides are secreted from gut endocrine cells and promote nutrient absorption through distinct mechanisms. Finally, the fourth peptide is similar to glicentin, an active enteroglucagon.Tissue specificity: Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP1 and GLP2 are also secreted in selected neurons in the brain.

Immunohistochemical Analysis :-1:200

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Secreted
Post transnational modification:	Proglucagon is post-translationally processed in a tissue-specific manner in pancreatic A cells and intestinal L cells. In pancreatic A cells, the major bioactive hormone is glucagon cleaved by PCSK2/PC2. In the intestinal L cells PCSK1/PC1 liberates GLP-1, GLP-2, glicentin and oxyntomodulin. GLP-1 is further N-terminally truncated by post-translational processing in the intestinal L cells resulting in GLP-1(7-37) GLP-1-(7-36)amide. The C-terminal amidation is neither important for the metabolism of GLP-1 nor for its effects on the endocrine pancreas.
Tissue Specificity:	Glucagon is secreted in the A cells of the islets of Langerhans. GLP-1, GLP-2, oxyntomodulin and glicentin are secreted from enteroendocrine cells throughout the gastrointestinal tract. GLP-1 and GLP-2 are also secreted in selected neurons in the brain.
BioGrid:	108911.19 interactions.

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