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当前位置: 首页 > 产品中心 > Microscope > 抗MBD1单克隆抗体(克隆:ABM15H2)/25µg/10-7007
商品详细抗MBD1单克隆抗体(克隆:ABM15H2)/25µg/10-7007
抗MBD1单克隆抗体(克隆:ABM15H2)/25µg/10-7007
抗MBD1单克隆抗体(克隆:ABM15H2)/25µg/10-7007
商品编号: 10-7007
品牌: Abeomics
市场价: ¥1800.00
美元价: 900.00
产地: 美国(厂家直采)
公司:
产品分类: 显微镜
公司分类: Microscope
联系Q Q: 3392242852
电话号码: 4000-520-616
电子邮箱: info@ebiomall.com
商品介绍

Format :Purified
Amount :100 µg
Isotype :Mouse IgG1 Kappa
Purification :Protein G Chromatography
Content :25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition :Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.
Gene :MBD1
Gene ID :4152
Uniprot ID :Q9UIS9
Alternative Name :MBD1, CXXC3, PCM1
Immunogen Information :A partial length recombinant MBD1 protein (amino acids 291-586) was used as the immunogen for this antibody.

MBD1 (Methyl-CpG-Binding Domain Protein 1) protein is a primary candidate for the readout of DNA methylation as it recruits chromatin remodelers, histone deacetylases and methylases to methylated DNA associated with gene repression. This protein, a member of a transcriptional repressor family MBD, is predominantly expressed in neurons. MBD protein binding requires both functional MBD domains and methyl-CpGs; however, some MBD proteins also bind unmethylated DNA and active regulatory regions via alternative regulatory domains or interaction with the NuRD/Mi-2 (Nucleosome Remodeling Deacetylase) complex members. The CXXC3 domain of MBD1 makes it a unique member of the MBD family due to its affinity to unmethylated DNA. MBD1 acts as an epigenetic regulator via different mechanisms, such as the formation of the MCAF1/MBD1/SETDB1 complex or the MBD1-HDAC3 complex. It also plays an important role in disease progression, contributes to the drug resistance of PC cells; however, the mechanism underlying the drug resistance endowed by MBD1 remains unknown.

Western blot analysis: 2-4 µg/ml, Immunohistochemical analysis: 5 µg/ml, Facs analysis:.0.5-1 µg/10^6 Cells

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:Nucleus, Nucleus matrix, Nucleus speckle, Chromosome
Post transnational modification:Sumoylated with SUMO1 by PIAS1 and PIAS3. Sumoylation affects transcriptional silencing by preventing the interaction with SETDB1. In contrast, sumoylation may increase interaction with AFT7IP.
Tissue Specificity:Widely expressed.
BioGrid:110322.30 interactions.
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品牌介绍
Abeomics由一组经验丰富的科学家组成,他们还建立了成功的全球业务,其中包括世界一流的生命科学试剂和合同实验室服务提供商IMGENEX Inc.,以及用于系统生物学和临床医学的复杂的交互式网络数据库Protein Lounge。生物信息学。