抗半胱天冬酶-3单克隆抗体（克隆：ABM11D3）/25µg/10-1004-免疫在线蚂蚁淘旗下平台

商品详细抗半胱天冬酶-3单克隆抗体（克隆：ABM11D3）/25µg/10-1004

抗半胱天冬酶-3单克隆抗体（克隆：ABM11D3）/25µg/10-1004

商品编号： 10-1004

品牌： Abeomics

市场价： ¥1800.00

美元价： 900.00

产地：美国(厂家直采)

公司：

产品分类：细胞凋亡

公司分类： Apoptosis

联系Q Q： 3392242852

电话号码： 4000-520-616

电子邮箱： info@ebiomall.com

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商品介绍

Format :	Purified
Amount :	100 µg
Isotype :	Mouse IgG1
Purification :	Protein G Chromatography
Content :	25 µg in 50 µl/100 µg in 200 µl PBS containing 0.05% BSA and 0.05% sodium azide. Sodium azide is highly toxic.
Storage condition :	Store the antibody at 4°C, stable for 6 months. For long-term storage, store at -20°C. Avoid repeated freeze and thaw cycles.


Gene :	CASP3
Gene ID :	836
Uniprot ID :	P42574
Alternative Name :	Apopain, Cysteine protease CPP32, SREBP cleavage activity, SCA-1
Immunogen Information :	Full length recombinant protein of Caspase-3was used as the immunogen for this antibody.

Caspases are a member of the cysteine-aspartic acid protease family. Caspase-3 (31 kDa) is an executionary caspase which directly cleaves and activates poly(ADP-ribose) polymerase (PARP), sterol regulatory element binding proteins (SREBPs) or it can also interact with other caspases like caspase-6, -7 and -9. Increased levels of caspase-3 are involved in Huntington Disease-associated cell death. Caspase-3 is the principal caspase in mediating the cleavage of amyloid-beta 4A precursor protein (APP), which is related with neuronal death in Alzheimer's disease. Like other caspases, caspase-3 is also synthesized as a zymogen procaspase which is activated by specific proteolytic cleavage. High levels of caspase-3 are observed in lung, spleen, heart, liver and kidney, moderate levels in brain and skeletal muscle, and low in testis.

WB: 0.5-4 µg/ml, FACS: 0.5-1 µg/10^6, IHC: 5-10 µg/ml

For Research Use Only. Not for use in diagnostic/therapeutics procedures.

Subcellular location:	Cytoplasm
Post transnational modification:	S-nitrosylated on its catalytic site cysteine in unstimulated human cell lines and denitrosylated upon activation of the Fas apoptotic pathway, associated with an increase in intracellular caspase activity. Fas therefore activates caspase-3 not only by inducing the cleavage of the caspase zymogen to its active subunits, but also by stimulating the denitrosylation of its active site thiol.
Tissue Specificity:	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
BioGrid:	107286.102 interactions.

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